Topoisomerase 2a
WebApplications. Use a concentration of 0.5 - 1 µg/ml. Predicted molecular weight: 174 kDa. Use a concentration of 0.5 - 1 µg/ml. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol. (Primary incubation for 30 min at RT). Use at an assay dependent concentration. WebJun 4, 2024 · In silico screening of the interactions with the target proteins tubulin, human topoisomerase II β and human ROCK1 via docking calculation permitted the selection of the new molecules 1a–c, 2a–c and 3 . Their drug-likeness was computationally predicted regarding the physico-chemical properties relevant for the development of a drug.
Topoisomerase 2a
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WebThis gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This nuclear enzyme is involved in processes such as chromosome condensation, chromatid separation, and the relief of torsional stress that occurs during DNA transcription and replication. It catalyzes the transient breaking and … WebApr 20, 2009 · Topoisomerase II poisons generate DNA damage, in addition to inhibition of enzyme activity, and would be expected to delay cell cycle progression by means of DNA damage checkpoints. 79,80,81 The ...
WebZone 2A = 0.15g D Zone 28 = 0.20g D Zone 3 = 0.30g II Zone 4 = 0.40g Source: 1997 Edition UBC NRC-070 Submitted: 5/8/2015-1-Kaua'l .SeattIe OlymÞia washing ton Portland Salem … WebSep 1, 2024 · However, recent studies have suggested that the topoisomerase 2a isozyme is predominantly responsible for the carcinogenic side effects associated with etoposide and doxorubicin chemotherapy. Thus, we need to find a promising topoisomerase 2-targeting anticancer agent that avoids these carcinogenic side effects. Recent studies have found …
WebJun 17, 2009 · Type II topoisomerases are ubiquitous enzymes that play an essential role in the control of replicative DNA synthesis and share structural and functional homology among different prokaryotic and eukaryotic organisms. Antibacterial fluoroquinolones target prokaryotic topoisomerases at concentrations 100- to 1000-fold lower than mammalian … WebFeb 27, 2024 · The type 2 DNA topoisomerases (Top2) are conserved enzymes and biomarkers for cell proliferation. The catalytic activities of the human isoform Top2a are essential for the regulation of DNA ...
WebJul 9, 2024 · 3A/2A East Northeastern Coastal: 3A - Currituck County, First Flight // 2A - Camden County, Edenton Holmes, Hertford County, Manteo, Northeastern, Pasquotank …
WebDas KMT2A-Gen (Lysin-Methyltransferase 2A) an 11q23.3 ist üblicherweise bei akuten Leukämien, insbesondere bei Säuglingsleukämie und bei sekundärer Leukämie, nach Behandlung mit DNA-Topoisomerase-II-Inhibitoren neu angeordnet1. Das KMT2A-Gen weist eine große Homologie mit dem Drosophila-Trithorax-Gen ini 4thWebSep 1, 2024 · DNA topoisomerase 2, which is ubiquitously expressed in eukaryotic cells, is an essential nuclear enzyme that promotes cell survival by regulating DNA topology and … in hypothroidism the thyroid gland producesWebProteomic Analysis Reveals that Topoisomerase 2A is Associated with Defective Sperm Head Morphology. Topoisomerase II contributes to DNA secondary structure-mediated … mls finder softwareType II topoisomerases are topoisomerases that cut both strands of the DNA helix simultaneously in order to manage DNA tangles and supercoils. They use the hydrolysis of ATP, unlike Type I topoisomerase. In this process, these enzymes change the linking number of circular DNA by ±2. … See more Type II topoisomerases increase or decrease the linking number of a DNA loop by 2 units, and it promotes chromosome disentanglement. For example, DNA gyrase, a type II topoisomerase observed in E. coli and most other See more There are two subclasses of type II topoisomerases, type IIA and IIB. • Type IIA topoisomerases include the enzymes See more Strand passage Type IIA topoisomerase operates through a "two-gate" mechanism (though this is a historical notation), … See more Small molecules that target type II topoisomerase are divided into two classes: inhibitors and poisons. Due to their frequent presence in proliferating eukaryotic cells, … See more Type IIA topoisomerases are essential in the separation of entangled daughter strands during replication. This function is believed to be … See more Type IIA Type IIA topoisomerases consist of several key motifs: • an … See more Catenation is the process by which two circular DNA strands are linked together like chain links. This occurs after DNA replication, where two single strands are catenated and can … See more mls fitchburg wiWebMar 27, 2024 · Topoisomerase II alpha (TOP2A) protein has been shown to be a proliferation marker associated with tumor grade and Ki67 index. ... [16, 28], thus could probably explain the poor correlation between TOP 2A protein expression and gene amplification. Since TOP2A protein represents the ultimate expression of TOP2A as well as tumor cell ... mls firstWebNov 15, 2011 · The HER2 amplicon on chromosome 17q is variable in size and occasionally includes Topoisomerase 2A (TOP2A) at 17q21-22. It has been suggested that TOP2 co-amplification, not HER2 amplification on … mls financeWebTopoisomerase II Alpha has been identified by DNA microarray and transcriptional profiling as a gene that is overexpressed in Cervical Carcinomas. The TOP2A gene is approximately 30 kb in size and encodes a 170 kDa protein. Topoisomerase II Alpha antibody is expressed in proliferating cells and in numerous human malignant tumors, including colon, gastric … mls find selling history