Tead2 protein
WebJun 15, 2024 · Tead1 and Tead2 can also interact with the p160 family of proteins, which consists of Src1 (Ncoa1), Src2 (Ncoa2; also known as Tif2, Grip1) and Src3 (Ncoa3; also known as Rac3, Aib1, pCIP, Actr) ( Belandia and Parker, 2000 ). The p160 proteins are co-activators that bind to nuclear receptors and promote transcription in a hormone … WebTEA Domain Transcription Factors (TEADs) are important in development and serve essential roles in tumorigenesis; however, the role of TEAD2 expression in …
Tead2 protein
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WebTEAD2 Antibody recognizes endogenous levels of total TEAD2 protein. This antibody does not cross-react with other TEAD family member proteins. Species Reactivity: Human. … WebNov 17, 2024 · Thus, TEAD2 and E2A promote tumorigenesis via inhibition of acetyl-CoA synthesis and protein acetylation. TEAD2 and E2A were previously implicated in …
WebFigure 6A has shown that the protein level of TEAD2 was significantly increased in OSC cell lines including A2780, TOV112D, SKOV-3 and OVCAR3 compared to normal ovary cell line IOSE80 (Supplemental Figure 1). Moreover, we explored the function of TEAD2 in OSC by knocking down the TEAD2 in A2780 cells (Figure 6B, Supplemental Figure 2). WebNov 18, 2024 · TEAD-YAP controls the expression of Hippo-responsive genes involved in cell proliferation, development, and tumorigenesis. Hyperactivation of TEAD-YAP activities is observed in many human cancers and is associated with cancer cell proliferation, survival, and immune evasion.
WebSep 8, 2024 · A previous study showed that TEAD2 protein level upregulation led to the nuclear accumulation of YAP and TAZ and triggered EMT (Diepenbruck et al., 2014), which impeded the MET process and repressed fibroblast reprogramming (Li et al., 2010). Therefore, we examined TEAD2-targeted EMT-related gene expression in our … WebJun 24, 2024 · The yes-associated protein (YAP) is a critical downstream target regulated by the Hippo signaling pathway. ... Besides, the expression of TEAD2 is associated with a poor prognosis in hepatocellular carcinoma patients, which can be considered as a therapeutic target of hepatocellular carcinoma . However, there are little data about the …
TEAD proteins are found in many organisms under different names, assuming different functions. For example, in Saccharomyces cerevisiae TEC-1 regulates the transposable element TY1 and is involved in pseudohyphale growth (the elongated shape that yeasts take when grown in nutrient-poor conditions). In Aspergillus nidulans, the TEA domain protein ABAA regulates the differentiation of conidiophores. In drosophila the transcription factor Scalloped is involved in th…
WebHuman TEAD2 full-length ORF ( NP_003589.1, 1 a.a. - 447 a.a.) recombinant protein with GST-tag at N-terminal. (H00008463-P01) - Products - Abnova Innovate through Integrated Solutions pine island lutheran churchtop news hotmailWebHuman cell lines. GENERAL INFORMATIONi. General description of the gene and the encoded protein (s) using information from HGNC and Ensembl, as well as predictions … pine island minnesota fox news storyWebFeb 22, 2016 · Recombinant GST-TEAD2 or His 6 TEAD2 (500 ng) protein was incubated with the indicated concentrations of alkyne palmitoyl-CoA (Cayman Chemical) for 2 h or … top news hindustan timeshttp://yuxiqbs.cqvip.com/Qikan/Article/Detail?id=7108599041 top news houstonWebNov 6, 2015 · We show that human TEADs are palmitoylated at a universally conserved cysteine, and report the crystal structures of the human TEAD2 and TEAD3 YAP-binding domains in their palmitoylated forms. These structures show a palmitate bound within a highly conserved hydrophobic cavity at each protein's core. Our findings also … top news hockeyWebTEAD-IN-2 (TEAD antagonist 2) is a small molecule TEAD antagonist (TEAD2 IC50=603 nM FP assays, SPR Kd=229 nM) that binds the TEAD lipid pocket and disrupts TEAD S-palmitoylation. TEAD-IN-2 showed similar IC50 against all TEAD paralogs TEAD1, TEAD3, and TEAD4 both in IP and SRP assays. TEAD-IN-2 disrupted Hippo signaling in a Detroit … pine island mn address little hair salon