WebThe stoichiometry of polyamine binding at which condensation of chromatin is completed is found to be two polyamine molecules per DNA turn. The extent of neutralization of the DNA phosphates by the histones in these compact fibers is estimated to be about 55%. The model of polyamine interaction with chromatin is discussed. WebNov 8, 2024 · Termed pacDNA (polymer-assisted compaction of DNA), these agents show improved biopharmaceutical characteristics and antisense potency in vivo while suppressing non-antisense side effects. Nonetheless, there still is a lack of the mechanistic understanding of the cellular uptake, subcellular trafficking, and gene knockdown with …
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WebJun 17, 2024 · We have developed a non-cationic transfection vector in the form of a bottlebrush polymer-antisense oligonucleotide (ASO) conjugate. Termed pacDNA (polymer-assisted compaction of DNA), these agents show improved biopharmaceutical characteristics and antisense potency in vivo while suppressing non-antisense side … WebAug 1, 1997 · The cationic polymers bind to DNA in a stoichiometry that is nearly 1:1 in primary amines to DNA phosphates. The apparent binding of all cationic polymers to DNA … dog boarding and training oceanside
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WebJun 13, 2024 · For a proof-of-concept demonstration, we adopted the ring-opening metathesis polymerization (ROMP) to facilely convert norbornene-modified, protected … WebJan 2, 2024 · The rheological properties were studied with the Anton Paar Modular Compact Rheometer equipment (MCR 102 parallel-plate ... non-histone nuclear protein that is tightly … WebTermed pacDNA (polymer-assisted compaction of DNA), these agents show improved biopharmaceutical characteristics and antisense potency in vivo while suppressing non … facts about vegetation