Glycogen phase separation and liver cancer
WebThus, we concluded that cancer-initiating cells adapt a glycogen storing mode, which blocks Hippo signaling through glycogen phase separation to augment tumor incidence. Original language: English (US) Pages (from-to) 5559-5576.e19: Journal: Cell: Volume: 184: Issue number: 22: ... Hippo signaling, liver cancer, Mst1, Mst2, phase separation", WebGlycogen accumulation and phase separation drives liver tumor initiation. Author links open overlay panel Qingxu Liu 1 7, Jiaxin Li 1 7, Weiji Zhang 1 7, Chen Xiao 1 7, Shihao Zhang 1 7, Cheng Nian 1, Junhong Li 1, Dongxue Su 1, Lihong Chen 2, Qian Zhao 3, Hui Shao 4, Hao Zhao 1, Qinghua Chen 1, Yuxi Li 1, Jing Geng 1, Lixin Hong 1, Shuhai Lin ...
Glycogen phase separation and liver cancer
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WebOct 30, 2024 · Introduction. Glycogen is a highly branched polymer of glucose that is used for the efficient storage and release of energy ().This function is highlighted by the … WebFeb 11, 2024 · Meanwhile, recent evidence that LLPS of glycogen can drive liver cancer initiation 90 potentially suggests much deeper links between LLPS and metabolic rewiring in cancer, highlighting the need ...
WebOct 21, 2024 · Europe PMC is an archive of life sciences journal literature. WebAug 1, 2024 · Thus, we concluded that cancer-initiating cells adapt a glycogen storing mode, which blocks Hippo signaling through glycogen phase separation to augment tumor incidence. View Show abstract
WebSep 5, 2024 · Glycogen metabolism has recently been linked to the modulation of epigenetics via nuclear glycogenolysis to supply acetyl-CoA (Sun et al , 2024 ), and liquid-phase separation of protein-bound glycogen is a driver of both liver tumorigenesis and proliferation (Liu et al , 2024 ). WebOct 26, 2024 · Consistently, elimination of glycogen accumulation abrogates liver growth and cancer incidence, whereas increasing glycogen storage accelerates tumorigenesis. Thus, they concluded that...
WebNov 8, 2024 · This assay provides robust and sensitive spatial glycogen quantification and architecture characterization in the brain, liver, kidney, testis, lung, bladder, and even the bone. Armed with this tool, we interrogated glycogen spatial distribution and architecture in different types of human cancers.
WebJul 14, 2024 · In addition to glycolytic enzymes, other proteins involved in glycogen metabolism, glycogen phosphorylases brain and liver form (PYGB, PYGL), and glycogen debranching enzyme (AGL),... burnt cookiesWebAtypical liver cancer fibrolamellar carcinoma ... DACT1: WNT signaling inhibition: Breast and prostate cancer : Glycogen compartments: G6PC: YAP signaling activation: Liver cancer : Stress granules: ... It is optimistic to envision that future in-depth investigations into cancer-associated phase separation and condensates will revolutionize our ... burnt copper next to aged brassWebConsistently, elimination of glycogen accumulation abrogates liver growth and cancer incidence, whereas increasing glycogen storage accelerates tumorigenesis. Thus, we concluded that cancer-initiating cells adapt a glycogen storing mode, which blocks Hippo signaling through glycogen phase separation to augment tumor incidence. burnt cones singaporeWebMar 7, 2014 · Glycogen is a hyperbranched glucose polymer comprised of glycogen β particles, which can also form much larger composite α particles. The recent discovery using size-exclusion chromatography (SEC) that fewer, smaller, α particles are found in diabetic-mouse liver compared to healthy mice highlights the need to achieve greater accuracy in … hamlin bank and trust online banking loginWebJan 12, 2024 · Major Finding: Glycogen is a key oncogenic metabolite in liver tumor initiation. Concept: Glycogen undergoes liquid–liquid phase separation and aggregates … burnt cones ice creamWebApr 5, 2024 · Correlations between changes in phase separation and carcinogenesis only recently attracted the attention of researchers, and, now, growing evidence is accumulating that cancer-associated... burnt copper hair colorWebDec 2, 2024 · From this day, research on glycogen function has progressed remarkably, especially with respect to its role in liver cancer and disease. Glycogen is comprised of … burnt cookies strain